Secondary metabolites of Bacillus subtilis impact the assembly of soil-derived semisynthetic bacterial communities

• Heiko T. Kiesewalter,
• Carlos N. Lozano-Andrade,
• Mikael L. Strube and
• Ákos T. Kovács

Beilstein J. Org. Chem. 2020, 16, 2983–2998, doi:10.3762/bjoc.16.248

• Lysinibacillus fusiformis M5 exposed to either spent media of the B. subtilis strains or pure surfactin indicated the sensitivity of this strain towards the biosurfactant surfactin. Our study provides a more in-depth insight into the influence of B. subtilis NRPs on semisynthetic bacterial communities and helps

• to understand their ecological role. Keywords: Bacillus subtilis; bacterial community; chemical ecology; Lysinibacillus fusiformis; nonribosomal peptides; surfactin; Introduction In nature, bacteria live in complex communities where they interact with various other microorganisms. Most microbial

• contained 13 genera with a relative abundance of >0.19% in at least one mock community. Furthermore, it was demonstrated that the addition of B. subtilis suppressed the genera Lysinibacillus and Viridibacillus. Additional optical density (OD)-based growth monitoring of the selected strain Lysinibacillus